Opioid receptor types and dependence.
نویسندگان
چکیده
منابع مشابه
Chimeric opioid peptides: tools for identifying opioid receptor types.
We synthesized several chimeric peptides in which the N-terminal nine residues of dynorphin-32, a peptide selective for the kappa opioid receptor, were replaced by opioid peptides selective for other opioid receptor types. Each chimeric peptide retained the high affinity and type selectivity characteristic of its N-terminal sequence. The common C-terminal two-thirds of the chimeric peptides ser...
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Recent data suggest that opioid receptors are involved in the development of nicotine physical dependence in mammals. Evidence in support of a similar involvement in an invertebrate (Planaria) is presented using the selective opioid receptor antagonist naloxone, and the more receptor subtype-selective antagonists CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) (μ, MOR), naltrindole (δ, DOR), and...
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INTRODUCTION Dependence on opioids is a multifactorial condition involving genetic and psychosocial factors. There are three stages to treating opioid dependence. Stabilisation is usually by opioid substitution treatments, and aims to ensure that the drug use becomes independent of mental state (such as craving and mood) and independent of circumstances (such as finance and physical location). ...
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Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been...
متن کاملParenthood and opioid dependence
INTRODUCTION Many patients in maintenance treatment programs for opioid dependence are parents to underage children. OBJECTIVE The aim of this study was to explore how parents who are regular patients in maintenance treatment perceive their parenthood. METHODS The study used a qualitative approach. The informants were recruited by staff at a substance abuse clinic in Sweden. Criteria for in...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1997
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.109.165